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In vivo therapeutic effect of the EFMs in a rat alveolar bone defect model. A) 3D reconstruction and sectioned views of the rat maxillary alveolar bones. B, C) Quantitative results calculated from micro-CT data: CEJ-ABC distance, BV/TV. D, E) H&E staining and quantitative analysis. F, G) Masson's trichrome staining and quantitative analysis. H-J) The immunofluorescence images and quantitative results of OPN and VEGF. K) Schematic illustration depicting the animal model establishment and the experimental process. Data are presented as mean ± SD. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001; ns, not significant.

Journal: Materials Today Bio

Article Title: Synergistic osteogenesis, angiogenesis, and immune reprogramming by a metal-phenolic functionalized electrospun fibrous membrane for alveolar bone regeneration

doi: 10.1016/j.mtbio.2026.103045

Figure Lengend Snippet: In vivo therapeutic effect of the EFMs in a rat alveolar bone defect model. A) 3D reconstruction and sectioned views of the rat maxillary alveolar bones. B, C) Quantitative results calculated from micro-CT data: CEJ-ABC distance, BV/TV. D, E) H&E staining and quantitative analysis. F, G) Masson's trichrome staining and quantitative analysis. H-J) The immunofluorescence images and quantitative results of OPN and VEGF. K) Schematic illustration depicting the animal model establishment and the experimental process. Data are presented as mean ± SD. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001; ns, not significant.

Article Snippet: The harvested maxillae were scanned using a micro-computed tomography (micro-CT) system (SkyScan1276, Bruker, USA) to evaluate alveolar bone regeneration.

Techniques: In Vivo, Micro-CT, Staining, Immunofluorescence, Animal Model